代做PHAY0033 Formulation of Small Molecules代做Statistics统计

PHAY0033

Formulation of Small Molecules

1)      Answer BOTH parts of this question

Onychomycosis is the most common nail disorder.   Dr  Murdan  at the  UCL School of Pharmacy has synthesised a new anti-onychomycotic drug molecule. Professor Basit has mixed the drug with excipients and prepared a formulation that will be directly printed onto patients’ onychomycotic nails.

a)        Discuss how the properties of the drug molecule might influence its ungual permeability.            (50% of marks)

b)        Discuss how the properties of the formulation might influence its efficacy. (50% of marks)

2)      You have been asked to develop an immediate relase tablet formulation

containing 250mg of drug X. The drug is freely soluble across the entire pH range of the gastrointestinal tract.  Propose, with appropriate justification, a suitable tablet formulation for drug X.                            (100% of marks)

3)       Explain TWO (2) formulation factors affecting oral transmucosal bioavailability. Give ONE (1) example of a formulation approach to improve oral trasmucosal absorption.   (100% of marks)

4)      Answer both parts of this question:

a)       Describe the two main formulation principles for dry powder inhalation (DPI), including in your answer the roles of forces of adhesion and cohesion (50% of marks)

b)       A  company  formulating  a  DPI  formulation  buys  milled  drug  from  a supplier. The supplier changes its mill to a newtype; it assures that the particle size distribution of the  milled drug  remains the same as  before,  but when formulated the performance of the DPI product is reduced. Explain why this might be the case and what you might do to improve the situation.

(50% of marks)